The Vikings placed offensive tackle Matt Kalil, who has started all 66 games during his NFL career, on injured reserve because of a hip injury Wednesday.
He will have surgery, coach Mike Zimmer said.
"We assume it will be," Zimmer said, when asked if the surgery was season ending.
T.J. Clemmings, who started last season at right tackle, will replace Kalil.
Not long after stepping to the podium and announcing Kalil's status — and that future Hall of Fame running back Adrian Peterson would have knee surgery that could end his season — Zimmer was asked what his message to the team on Wednesday morning. He gave a defiant shrug, signifying the NFL's next-man-up mantra.
"I feel like we have to go back to work and go play Carolina," Zimmer said. "I expect [the players] to perform the way I always expect them to perform."
Clemmings was thrust into the starting lineup as a rookie in the preseason a year ago when right tackle Phil Loadholt went down for the season. Although Clemmings played all 17 games, including the playoff loss to Seattle, he struggled with speed rushers and stunts that defenders used to cross up protection schemes.
The Vikings then replaced him in free agency with former Bengals tackle Andre Smith. Clemmings competed for the starting job, but had to settle for being the swing tackle even though his only experience with left tackle was at the Senior Bowl in 2015.