Bet them to cover a 16½-point spread at your own risk. But with rookie Josh Allen making his second career start, at U.S. Bank Stadium, behind a line that's given up its fair share of pressure in the first two weeks of the season, the Vikings should cruise at home.
THREE BIG STORY LINES
Bailey debuts as kicker
After Daniel Carlson's three missed field goals at Lambeau Field cost him his job last week, the Vikings signed veteran Dan Bailey to a one-year, $1.75 million deal this week.
Frazier serves as 'collaborating' coordinator
Former Vikings coach Leslie Frazier, who was fired after the 2013 season, is the Bills' defensive coordinator, but after Buffalo's atrocious defensive start last week, coach Sean McDermott took defensive play-calling duties from Frazier. They will continue "collaborating" on defensive plays this week.
Tall task for Allen
The seventh overall pick in the 2018 draft, Allen completed 18 of 33 passes for 245 yards, a touchdown and two interceptions in his first NFL start last week. He took five sacks at home against the Chargers; he'll make his first start on the road.
TWO KEY MATCHUPS
Vikings LT Riley Reiff vs. Bills DE Jerry Hughes