So how big a difference is having 0.37 to 0.22 fewer seconds in which to accomplish this task?
Ask Kirk Cousins and Aaron Rodgers. That's how long the 49ers' first two playoff victims had to throw, on average, respectively, in a pair of 17-point beatdowns of the Vikings and Packers.
Next up is a Super Bowl LIV showdown that many believe will be won by whichever side prevails in the marquee matchup between Kansas City's blistering speed on offense and San Francisco's quickness to the quarterback on defense.
"Everybody has been trying to scheme up on us with different defenses for two years," Chiefs receiver Sammy Watkins said. "But we don't fear what anyone brings at us. If we play the way we know we can play, we should be fine.
"When you have this many track guys out there running full speed and you also have Patrick Mahomes, one of the most prolific quarterbacks, scrambling and getting out of the pocket, it's usually five guys out there and maybe four of them are open."
Cousins was sacked six times by five linemen drafted in the first round. Rodgers was felled three times, twice while trailing 27-0 at the half.
"The fact that we have the ability to rush [effectively] with only four guys is a big advantage," said defensive end Dee Ford, who was traded from the Chiefs to the 49ers last March. "Then we can sprinkle in some blitzes that will confuse the play-caller and the thrower of the ball."
According to Pro Football Focus, the 49ers rank second in defensive passer rating when the enemy passer has 2.5 seconds or fewer to throw. But PFF also notes that, in Sunday's case, the enemy passer is reigning league MVP Mahomes, whose passer rating with 2.5 seconds or fewer is 120.3 over the past two years.