The Vikings will likely be without two offensive starters Sunday against the Panthers, and coaches are still waiting to learn whether they'll be down a third in receiver Adam Thielen.
Right guard Ezra Cleveland has been ruled out after being unable to practice for a second straight week because of an ankle injury he played through in the Nov. 16 win at Chicago. He'll be replaced again by veteran Brett Jones, who last Sunday started his first game in two years.
Tight end Irv Smith Jr. is expected to miss his second game in three weeks. He is listed doubtful while dealing with groin and back injuries, the latter picked up after returning last game. He was unable to practice this week outside of Wednesday's limited session. The coaching staff trusts third-year tight end Tyler Conklin, who played 46 snaps in Chicago, to step into a big role.
"[Conklin] is doing really well," offensive coordinator Gary Kubiak said. "He's got a bright future. I see him as a guy who can do a little bit of everything. He can play on the line of scrimmage, run good routes, got good hands. … I really like how he works. He's playing behind a couple good players."
Thielen's availability may be in question until Sunday morning, coach Mike Zimmer said, as the Vikings await results of daily coronavirus tests that will determine whether Thielen needs to remain quarantined. He hasn't been ruled out yet.
"We'll just have to see," Zimmer said Friday. "He's going through the protocol. We'll just have to see how it goes on Sunday."
For the Panthers, guard Dennis Daley (concussion) is out; cornerback Donte Jackson (toe) is doubtful; seven are questionable in running back Christian McCaffery (shoulder), tackle Russell Okung (calf), guard John Miller (knee/ankle), linebacker Tahir Whitehead (rib), receiver Brandon Zylstra (shoulder), safety Sam Franklin (ankle) and defensive end Marquis Haynes (shoulder).
McCaffery has missed eight games this season because of injuries, and Panthers head coach Matt Rhule said Friday he expects McCaffery to miss his ninth Sunday despite being listed questionable.