Josh Donaldson missed the past four Twins games after straining his right hamstring during a 6-3 loss Saturday in Kansas City.
The third baseman could return to the lineup Thursday when the Twins open a four-game series at Target Field against the Tigers.
Twins manager Rocco Baldelli said before Wednesday's 6-1 loss to the White Sox that Donaldson would have been available to hit off the bench in the past two games. He will go through a full workout before Thursday's game and, if all goes well, Baldelli said, "we're pretty close to getting the thumbs-up on letting him loose."
In his past seven games, Donaldson is hitting .318 with seven hits, five runs, four walks and eight strikeouts.
Rocco on Chicago
This series was the fourth of five between the Twins and White Sox, with Chicago winning 10 of 12 games and four of six at Target Field.
The AL Central-leading White Sox are eight games ahead of second-place Cleveland, while Minnesota sits in last place in the division, 15½ games behind.
Baldelli credited the "unlikely" heroes of Chicago as part of what makes them tough to beat. And then there's the pitching staff, which is fourth in the majors in strikeouts with 842.
"They have some good arms," Baldelli said. "They go out there and compete very well and hold the opposition down.