Minnesota health officials announced another 1,306 confirmed COVID-19 cases and nine deaths Friday.
Reports of new first and second doses increased by nearly 38,000, bringing the percentage of fully vaccinated state residents to 51.2% of those over the age of 15.
Minnesota begins its first day without a mask mandate, nearly 300 days after the mask order was issued last July.
It remains to be seen how businesses and local governments will react, but Minneapolis and St. Paul have already said that they will keep a mask requirement in place.
Metro Transit said that masks will still be required on buses, trains and at transit waiting areas under federal guidelines.
Health care and long-term care settings will also continue to require employees, patients and guests to wear masks.
"The new guidance loosens restrictions associated with wearing masks indoors in certain settings and does not include health care settings at this time," the Mayo Clinic said in a statement. "At Mayo Clinic, the requirement for masking in health care facilities remains in effect, and infection control is reviewing and updating our policies continuously."
Minnesota Health Commissioner Jan Malcolm said that as demand for COVID-19 vaccine has slowed, some vaccinators are requesting fewer doses.