Short on sleep and down three starters, the Twins beat Central Division challenger Cleveland 7-6 on Thursday on Willi Castro's walk-off sacrifice fly at Target Field.
Trailing 6-3 after the Guardians' five-run sixth inning, the Twins rallied to win without Byron Buxton, Carlos Correa and Max Kepler, all of three of whom left the game because of injury or illness.
The Twins persevered, with a three-run, eighth inning that featured rookie Royce Lewis' tying two-run homer and Castro's long fly to right-center field on a 1-2 count, with the bases loaded and no outs in the bottom of the ninth.
The Twins now lead second-place Detroit by 2 1/2 games and third-place Cleveland by 4 1/2 in the Central Division.
There was not an available bench player left when Twins manager Rocco Baldelli sent catcher Ryan Jeffers to third to run for Christian Vázquez.
"Things weren't looking good in that game," Baldelli said. "We were behind and we had guys come in and start whacking the ball around, swinging at good pitches and hitting them hard. We always talk about finding a way in this game. This is probably a good textbook example of that."
Buxton left the game in fifth inning after he was hit on the rib with a pitch from Guardians starter Tanner Bibee. He'll have a medical imaging scan Friday morning, Baldelli said.
Afterward, Buxton said, "I feel all right," and was asked about the pain.