Vikings running back Dalvin Cook has been ruled out for Sunday's game against the Falcons after he was sidelined from practices this week because of a groin pull suffered in last week's loss at Seattle.
Cook is one of two starters ruled out for the Vikings offense against Atlanta. Right guard Dru Samia did not practice Thursday or Friday because of a wrist injury that popped up midweek, and he will be sidelined, meaning the Vikings will start a third different offensive line combination in the sixth game.
Receiver K.J. Osborn and cornerback Kris Boyd also will not play against the Falcons because of hamstring injuries. Cornerback Holton Hill (foot) is listed as doubtful.
Running back Alexander Mattison, who had a career-high 20 carries for 112 rushing yards in relief of Cook at Seattle, will get his first NFL start.
Cook, the NFL's leading rusher with 489 yards, will get at least two weeks' rest with the Week 7 bye. When asked whether Cook is expected to play against the Packers on Nov. 1, head coach Mike Zimmer responded, "How would I know? I'm just trying to do today and this week."
The Falcons defense has been vulnerable, allowing 32.2 points per game, but a new interior offensive line starter — possibly second-round rookie Ezra Cleveland or veteran Brett Jones, who got reps at guard this week — will face one of the NFL's best defensive tackles in Atlanta's Grady Jarrett.
"He's a great player, very quick, very powerful," Zimmer said. "They've got a lot of weapons, bring five guys a lot of times, play a lot of single-high [safety] and man-to-man, so it will be a good test for us. They'll have extra guys in the box for us, for sure."
Kickoff remains scheduled for noon at U.S. Bank Stadium after the Falcons reopened facilities Friday morning in Flowery Branch, Ga., when Thursday's COVID-19 tests returned negative. The NFL closed Atlanta's facilities on Thursday, after Wednesday's tests turned up a second confirmed positive for the week.