The injury-riddled Vikings lost three more starters during Sunday's 30-24 loss to the Lions.
Receiver Jordan Addison (ankle), tight end T.J. Hockenson (knee) and edge rusher D.J. Wonnum (quad) will require further examination on Monday, according to head coach Kevin O'Connell, after early exits in the loss.
The Vikings fear a significant quadriceps injury to Wonnum, O'Connell said.
"That is what makes losses like these hurt," O'Connell said. "And when a couple of their brothers go down — three, four guys go down with what may be significant injuries — it takes a lot to continue to persevere and push through."
Wonnum, who has eight sacks in 13 starts this season, went down in the fourth quarter. He buckled to the turf while rushing Lions quarterback Jared Goff, clutching his left leg. He was quickly carted off the field.
Receiver K.J. Osborn stepped into a larger role when Addison limped off the field in the second quarter. Osborn finished with five catches for 95 yards and his first touchdown since the Sept. 24 loss to the Chargers. The injuries keep role players like Osborn flexible.
"I got to move positions," Osborn said. "Earlier in the season, I was at [flanker]. Then Justin went down, I was at [split end]. ... Then Jordan goes down, so I'm back to [flanker]. I try to pride myself on knowing all the positions."
Hockenson took a helmet to the knee from Lions safety Kerby Joseph during a low tackle amid a 24-yard catch and run. Hockenson, who played through two injured ribs earlier this season, was quickly ruled out.