COVID-19 ended the year in Minnesota with an 8% increase in cases in December compared to last year, when vaccines were just beginning to become available.
The late 2021 reversal was a marked contrast from six months ago, when many Minnesotans were feeling optimistic that the pandemic would finally fade away.
Masks had come off, restaurants and bars were busy and fans enjoyed the normalcy of watching the Twins at Target Field.
June saw just 4,231 new COVID-19 cases in the state, an 80% drop from May and the lowest monthly tally since the pandemic was first detected here in March 2020.
But COVID-19 continued to surprise, as it has done all along, and 2021 stopped being a year of hope with the virus offering up two new highly contagious variants, the second even more infectious than the first.
"2021 was the year of hope and optimism with the vaccines and that was a really important pivot point because all of a sudden we have a tool that could change the landscape," said Minnesota infectious disease director Kris Ehresmann.
From her perspective as an epidemiologist, the relaxation of COVID-19 safety measures and the desire to move on from a relentless disease put everyone at risk.
"It was too early for some of those decisions and I think we were a little concerned about how that would play," she said. "We saw with delta ... and the elimination of most of the mitigation, it was kind of a perfect storm for that variant to gain a foothold."