The closure of schools and many businesses has meant the cancellation of hundreds of blood drives, putting pressure on the region's blood banks.
"This is unprecedented in the history of the Red Cross," said Carrie Carlson-Guest of the American Red Cross Minnesota Region.
Since the arrival of COVID-19, 295 Red Cross blood drives in Minnesota and the Dakotas have been canceled, resulting in an estimated loss of 9,800 donors.
Blood drives are an essential component of the voluntary blood-collection system, and many organizations sponsor them as a form of community service.
While the number of people who participate in drives may vary, it is unusual to have so many drives canceled in a short period.
"Over half of the blood that we collect comes from drives," said Erica Buege of Memorial Blood Centers, Minnesota's other large nonprofit blood bank.
"High schools and universities are huge supporters of ours," she said. "They host blood drives for students and staff all the time."
Be The Match, which relies on volunteers for bone marrow transplants, has also been significantly affected. It relies on college events — now canceled — to recruit potential donors for its registry. And it has faced difficulty making arrangements for matched donors because of travel restrictions and canceled flights.