Minnesota temporarily suspended use of the Johnson & Johnson COVID-19 vaccine Tuesday while federal authorities investigate whether six unusual blood clots among 7 million U.S. recipients should inhibit its continued use.
The U.S. Centers for Disease Control and Prevention and the U.S. Food and Drug Administration urged the pause because of the rare blood clots found in women 18 to 48 within six to 13 days of being vaccinated.
While the rate of these potential vaccine-related clots appears lower than their general occurrence in the U.S., health authorities said the pause is warranted to alert people to the symptoms and to warn doctors to avoid the use of the common blood thinner heparin to treat them.
"If you experience symptoms including severe headaches, abdominal pain, leg pain or shortness of breath within three weeks of getting Johnson & Johnson vaccine, we want to you to check it out with your health care provider," said state Health Commissioner Jan Malcolm, who received the J&J vaccine March 10.
The six U.S. cases included one death and one person hospitalized in critical condition. None involved people in Minnesota, where at least 184,000 have received J&J shots.
While the single-dose J&J vaccine represented only 5% of the 3.3 million doses administered in Minnesota so far, its supplies were increasing and the suspension will disrupt the state's vaccination progress. Roughly 18,200 doses had been slated for delivery to providers in Minnesota this week through the state and a federal pharmacy contract.
Malcolm said providers would reschedule upcoming appointments, though she expected the pause to last only a few days while federal authorities assess any risks and determine if they outweigh the benefits of J&J vaccine to the population as a whole or specific demographic groups.
A CDC advisory committee will meet Wednesday to review the six adverse events, which involved a type of clot known as cerebral venous sinus thrombosis (CVST) that occurred in combination with low levels of blood platelets. CVST affects the venous sinuses that drain blood from the brain.